Public Charity

CRITICAL PATH INSTITUTE

CRITICAL PATH INSTITUTE is a Public Charity headquartered in TUCSON, AZ. Financial data from the 2025 filing: $46.8M revenue, $40.2M expenses, $38.4M total assets. 44 publicly reported grants to this organization, totaling roughly $9.2M, appear in IRS filings.

EIN: 201991334 TUCSON, AZ Medical Research N.E.C. NTEE: H99 Latest filing: 2025
Total Revenue$46.8M
Total Expenses$40.2M
Total Assets$38.4M
Grant Records44
Funding Total$9.2M
Filing Years2021–2025

Mission

THE CRITICAL PATH INSTITUTE IS A CATALYST IN THE DEVELOPMENT OF NEW APPROACHES THAT ADVANCE MEDICAL INNOVATION AND REGULATORY SCIENCE. THIS IS ACHIEVED BY LEADING TEAMS THAT SHARE DATA, KNOWLEDGE AND EXPERTISE RESULTING IN SOUND, CONSENSUS BASED SCIENCE.

Where $100 goes at Critical Path Institute

How Critical Path Institute divides every $100 it spends, from its own Form 990 filings, averaged across 9 years.

$80 Programs the work itself
$20 Management running the organization
$0 Fundraising none reported

No fundraising costs are reported. That often means fundraising runs through a separate affiliated organization that files its own return.

Inside the $80 for programs

$40
Critical Path Institute also executes other projects and consortia in areas including therapeutics for the ataxias, polycystic kidney disorder, alzheimer's disease, parkinson's, tb, sickle cell disease, type 1…
50% of program spending
$17
Critical path for rare neurodegenerative diseases (cp-rnd)
22% of program spending
$16
Rare disease cures accelerator-data and analytics platform (rdca-dap) - Rdca-dap is an fda-funded initiative that provides a centralized and standardized infrastructure to support and accelerate rare disease characterization…
19% of program spending · Reported in the filing: 37,344 attendees

Plus 1 more program. Cost per person served and the full program breakdown are on the full profile.

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Source: Form 990 filings with the IRS, latest fiscal year 2025. Shares are from the organization's reported expenses. Data by Imperigo; not affiliated with the IRS.

Sample Grants Received

2025
Hereditary Spastic Paraplegia (HSP) and Primary Lateral Sclerosis (PLS) Taskforce to create a consortium between leading academic institutions, pharmaceutical industries, patient groups, non-governmental agencies and regulatory agencies to address unmet drug development needs for patients living with HSP and PLS.
$500,000
2025
RESEARCH- SUPPORT OF DUCHENNE REGULATORY SCIENCE CONSORTIUM
$100,000
$1,813,760
$500,000
2024
SUB-AWARD
$345,997

Showing up to 5 of 44 total records — full history available with membership.

Officers & Directors

VP PROGRAMS Dr Cheryl Coon
EXECUTIVE DIRECTOR Dr Diane Stephenson
BOARD MEMBER Dr Karen Bernstein
CEO Dr Klaus Romero
EXECUTIVE DIRECTOR Dr Maaike Everts
EXECUTIVE DIRECTOR Dr Marco Schito

Officer compensation and complete director data available with membership.

Top Grant Purposes

Research & Policy
$4,392,119 17 grants
Health & Medicine
$2,327,192 7 grants
General Support
$633,389 7 grants
Fundraising & Sponsorship
$415,000 6 grants
Unspecified
$1,434,757 7 grants

Financial Trends

Year Revenue Expenses Assets
2025 $46.8M $40.2M $38.4M
2024 $42.6M $38.3M $31.3M
2023 $35.3M $32.0M $26.7M
2022 $31.2M $29.6M $20.0M
2021 $24.4M $23.0M $18.5M

Between 2021 and 2025, reported annual revenue grew from $24.4M to $46.8M (+92%), with total assets most recently reported at $38.4M.

Interactive year-over-year charts and full filing details available with membership.

See the full picture for CRITICAL PATH INSTITUTE

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